Collaborative Clinical Cancer Trials Conference
between the US and Japan in Karuizawa
Recent Results and Future Directions of Common Arm Trials
-Final Program-
Date: September 7-8, 2007
Location: Kajima no Mori Hall, Hotel Kajima no Mori, Nagano, Japan
September 7(Fri), 2007
12:30
Opening remarks
Dr. Hiromi Wada
Chairman
Japan-Multinational Trial Organization (JMTO)
Session I
Gastric Cancer
12:40-14:00
Chairpersons:
Dr. Seiji Satoh
Dr. Yung-Jue Bang
12:40
1）
Combination therapy with S-1 and other cytotoxic drugs overcomes
tumor cell resistance to fluoropyrimidines in vivo
Dr. Masakazu Fukushima
Tokushima Research Center, Taiho Pharmaceutical Co., Ltd.
Dr. Hiromi Wada
Kyoto University
13:00
2）
A Phase II common arm trial of neoadjuvant chemotherapy for
resectable advanced gastric cancer using S-1/CDDP
Dr. Seiji Satoh
Akita University Hospital
13:20
3）
S-1 in gastric cancer chemotherapy
Dr. Hyun C. Chung
Yonsei University College of Medicine
13:40
4）
International collaboration for gastric cancer trials
Dr. Yung-Jue Bang
Seoul National University Hospital
Session II
Endoscopic Study for Lung Cancer
14:00-14:40
Chairpersons:
Dr. Thomas G. Sutedja
Dr. Seiki Hasegawa
14:00
1）
Evaluation of mediastinal nodal metastasis with endobronchial
ultrasound guided transbronchial needle aspiration (EBUS-TBNA)
in operable lung cancer patients
Dr. Fumihiro Tanaka
Hyogo College of Medicine
14:20
2）
Minimal invasive T and N working concepts
Dr. Thomas G. Sutedja
VU University Academic Medical Center
Session III
Clinical Trials
14:40-15:40
Chairpersons:
Dr. John J. Crowley
Dr. Satoshi Teramukai
14:40
1）
Issues in the analysis of molecular epidemiologic data
Dr. Mary W. Redman
Fred Hutchinson Cancer Research Center
15:00
2）
Clinical trial designs for targeted agents
Dr. John J. Crowley
Cancer Research And Biostatistics (CRAB)
15:20
3）
Perspective on Lung Cancer Management in Japan
Dr. Ryosuke Tsuchiya
National Cancer Center Hospital
15:40-15:50 -Coffee Break-
Session IV
Non-Small Cell Lung Cancer - I and Small Cell Lung Cancer
15:50-17:50
Chairpersons:
Dr. Tetsuya Mitsudomi
Dr. Fumihiro Tanaka
15:50
1）
Mutations of the EGFR or related genes and targeted therapy of lung cancer
Dr. Tetsuya Mitsudomi
Aichi Cancer Center Hospital
16:10
2）
Prevalence of EGFR gene mutations on surgical specimens.
Experience in Kyoto University Hospital
Dr. Makoto Sonobe
Kyoto University Hospital
16:30
3）
A phase II trial of pre-operative chemoradiotherapy followed by
surgical resection in patients with superior sulcus non-small cell lung
cancers: report of a Japan Clinical Oncology Group trial (JCOG 9806)
Dr. Masahiro Tsuboi
Tokyo Medical University & Hospital
16:50
4）
Surgical treatment of Pancoast tumor ―Surgical approach with
combination of open thoracotomy and VATS―
Dr. Seiki Hasegawa
Hyogo College of Medicine
17:10
5）
International randomized study to compare Cyberknife Stereotact Radiosurgery with surgical resection in stage I non-small cell lung cancer
(Lung Cancer STARS Trial)
Dr. Jack A. Roth
The University of Texas MD Anderson Cancer Center
17:30
6）
Current status and future directions of treatment for relapsed small-cell
lung cancer (SCLC)
Dr. Koichi Goto
National Cancer Center Hospital East
Session V
Key Note Address
17:50-18:10
Chairperson:
Dr. Hiromi Wada
17:50
Possibility for joint US-Japan global trials
Dr. Nagahiro Saijo
National Cancer Center Hospital East
19:00-21:00 -Banquet-
September 8(Sat), 2007
Session VI
8:00-10:00
Chairpersons:
Dr. David R. Gandara
Dr. Masaaki Kawahara
1)
Common Arm Trials (CATs) in Japan and the US
8:00
1A)
Rationale for Common Arm Studies
Dr. David R. Gandara
University of California Davis Cancer Center
8:10
1B)
The four-arm cooperative study (FACS) for advanced non-small cell
lung cancer
Dr. Kaoru Kubota
National Cancer Center Hospital East
8:30
1C)
JMTO LC00-03 Trial including QOL
Dr. Masaaki Kawahara
Nat’l Hospital Org. Kinki-chuo Chest Medical Center
8:50
2)
Pharmacogenomic analysis of Japan-SWOG common arm study in
advanced stage Non-Small Cell Lung Cancer (NSCLC)
Dr. Philip C. Mack
University of California Davis Cancer Center
9:10
3)
Common arm trials in the US and Japan
Dr. David R. Gandara
University of California Davis Cancer Center
9:20
4)
International trials for non-small cell lung cancer in Japan
Dr. Masahiro Fukuoka
Sakai Hospital, Kinki University School of Medicine
9:40
5）
Newer clinical trial infrastructure and paradigm in Japan―The role of
the Translational Research Informatics Center
Dr. Masanori Fukushima
Translational Research Center, Kyoto University &
Translational Research Informatics Center, Kobe
10:00-10:10 -Coffee Break-
Session VII
Non-small Cell Lung Cancer - III
10:10-10:50
Chairpersons:
Dr. Yukito Ichinose
Dr. Kaoru Kubota
10:10
1）
Phase II study of docetaxel and S-1 combination therapy in patients
with previously treated non-small-cell lung cancer
Dr. Shinji Atagi
Nat’l Hospital Org. Kinki-chuo Chest Medical Center
10:30
2）
Recent results and new trends of neoadjuvant and adjuvant
chemotherapy for early stage NSCLC in Japan
Dr. Yukito Ichinose
National Kyushu Cancer Center
Session VIII
Small Cell Lung Cancer -LD -
10:50-11:30
Chairpersons:
Dr. Primo N. Lara, Jr.
Dr. Yasushi Nagata
10:50
1）
A Phase II study of accelerated high dose thoracic irradiation with
concurrent chemoradiotherapy for patients with LD SCLC as a common
arm trial of the US trial
Dr. Yasushi Nagata
Graduate School of Medicine, Kyoto University
11:10
2）
Recent JCOG trials of combined modality treatment for limited small-cell
lung cancer
Dr. Kaoru Kubota
National Cancer Center Hospital East
11:30-12:30 -Lunch-
Session IX Small Cell Lung Cancer -ED-
12:30-13:10
Chairpersons:
Dr. Primo N. Lara, Jr.
Dr. Tadashi Mio
12:30
1）
Recent trials of chemotherapy for extensive small cell lung cancer in
the JMTO
Dr. Tadashi Mio
Graduate School of Medicine, Kyoto University
12:50
2）
Cisplatin (Cis)/etoposide (VP16) vs. cis/irinotecan (CPT11) in
extensive stage small cell lung cancer (E-SCLC): pharmacogenomic
(PG) and comparative toxicity analysis of JCOG 9511 and SWOG 0124
Dr. Primo N. Lara, Jr.
University of California Davis Cancer Center
Session X
Prognostic Index of Ovarian Cancer and Ethnicity,Gender or Other Factors for the Innovating Therapy of Lung Cancer
13:10-14:20
Chairpersons:
Dr. Philip C. Mack
Dr. Tadashi Mio
13:10
1)
PIEPOC: A New Prognostic Index for Advanced Epithelial Ovarian
Cancer−JMTO OC01-01
Dr. Satoshi Teramukai
Kyoto University Hospital
13:30
2）
Significant influence of smoking status and gender on the clinical
outcome in the patients with non-small cell lung cancer:
A comprehensive analysis of the 25554 Japanese patients
Dr. Tomoya Kawaguchi
Nat’l Hospital Org. Kinki-chuo Chest Medical Center
13:50
3）
S0424: Molecular Epidemiology in Women and Men, Smokers and
Never Smokers with NSCLC
Dr. David R. Gandara
Southwest Oncology Group(SWOG)
14:10
Closing Remarks
Dr. Masaaki Kawahara
Executive Director
Japan-Multinational Trial Organization (JMTO)
